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Related post: □ (•) HUVAN SUBJECTS
13 (tl) HIt.ORS Q (i2) IMERVIEWS
SUH"Afir Of VCHK (^PO ^0,-xii or Icis
n (t>) Xeloda Tablets HUHAN T ISSUES
\^ (c) NEITHER
A new ts donor virus that had been shown to be more stable in vivo and in vitro
than the ts-UEJ and ts-lA2 donor viruses nonetheless lost i'ts t£ phenotype after in
vitro stress at restrictive temperature. Its t£ phenotype was also lost Xeloda Tablet during
replication in vivo in cyclophosphamide treated hamsters. For these reasons work
with ts mutants fias been terminated. A reassortant virus containing the
hemagglutinin and neuraminidase genes of a virulent human virus and the six internal
genes of an attenuated avian virus was produced. This reassortant was attenuated and
immunogenic in the hamster. This avian-human reassortant virus lost its
enterotropism for ducks Order Xeloda but Xeloda Cancer retained its bursal tropism. Xeloda 500mg Additional avian-human
reassortants Xeloda Cost were produced for use in the characterization of the genetic
determinants of virulence of influenza A viruses for primates and for ducks.
Synthetic peptides of the A/Victoria/75 (H3) hemagglutinin were administered to
hamsters. The hamsters did not develop an HI antibody response and manifested only
minimal resistance to wild type challenge.
(rev. ,c. /C)
h' " T!-; AND h-'-'A'; SUUlCtS
f^'I.IC PEALTH £i.RVlCE
IKTTA'.a'r.AL RtSfARCH F'r.PJECT
ZOl AI 00325-01 LID
October 1, 1981 through September 30, J 982
iTllVw^ (KO.IICI (fcO ct.«f.clcr» or lrtARSi
CHICK APPROFRIAIE ECx(£S)
□ (.) HUMAN SUBJECTS G (b) HUHAN T I SSUt S B(c)f.CnHLR
|3(il)HlNCRS D ('^^J INTCRVICWS
SUy"AF,Y Xeloda Capecitabine 500mg OF VOHK (200 ^^,Xeloda 5 Fu s and the " internal" six genes from an attenuated avian virus was evaluated
for virulence in squirrel monkeys . The reassortant virus replicated to the Buy Xeloda same level
as its avian Xeloda Price parent and was fully attenuated in monkeys. These results indicated that
the Price Of Xeloda internal genes of the avian influenza A virus were the primary determinants of
attenuation for the monkey. Squirrel Cost Of Xeloda monkeys infected with the reassortant virus were
resistant to wild type virus challenge. This represents a new method for the production
°^ ^ '^'yg influenza A vaccine virus in which attenuating avian genes are transfered to
a human virus. The resulting reassortant virus is attenuated but immunogenic in
primates (and, hopefully, man).
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